Barbosa Filho J, Barbosa P R, Soares J P
Serviço de Cardiologia do Hupe-Verj, Rio de Janeiro, Brasil.
Rev Port Cardiol. 1992 Nov;11(11):963-6.
The purpose of this study was to analyse the effects of amiodarone on the treatment of cardiac failure. The effects of 200 mg/day of amiodarone were assessed in 18 patients with a history of cardiac failure. Functional class, heart rate, blood pressure, left ventricular ejection fraction, heart size, treadmill exercise tolerance and electrocardiogram were assessed before and eight weeks after the use of amiodarone, and the side effects were monitored. In 18 patients receiving amiodarone, the functional class and heart rate decreased significantly (p < 0.05) from 2.7 +/- 0.4 to 1.2 +/- 0.4 and 103 +/- 15 to 69 +/- 8.5 beats/min respectively. The ejection fraction and the exercise tolerance increased significantly (p < 0.05) from 29.2 +/- 5.5% to 41.5% and from 379.8 +/- 271 sec to 897.8 +/- 350.8 sec respectively. The incidence of atrial and ventricular arrhythmias decreased significantly and no side effects were observed. Amiodarone appears to produce benefits in patients with cardiac failure with atrial and ventricular arrhythmias.
本研究的目的是分析胺碘酮对心力衰竭治疗的效果。对18例有心力衰竭病史的患者评估了每日200毫克胺碘酮的效果。在使用胺碘酮前及使用八周后评估了心功能分级、心率、血压、左心室射血分数、心脏大小、平板运动耐量及心电图，并监测了副作用。在18例接受胺碘酮治疗的患者中，心功能分级和心率分别从2.7±0.4显著降至1.2±0.4（p<0.05），从103±15次/分钟降至69±8.5次/分钟。射血分数和运动耐量分别从29.2±5.5%显著增至41.5%，从379.8±271秒增至897.8±350.8秒（p<0.05）。房性和室性心律失常的发生率显著降低，且未观察到副作用。胺碘酮似乎对伴有房性和室性心律失常的心力衰竭患者有益。
