头孢呋辛酯固体状态稳定性的评估。
Evaluation of stability of cefuroxime axetil in solid state.
作者信息
Zajac Marianna, Jelińska Anna, Dobrowolski Leszek, Oszczapowicz Irena
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medical Sciences in Poznań, Grunwaldzka 6, 60-780 Poznań, Poland.
出版信息
J Pharm Biomed Anal. 2003 Aug 21;32(6):1181-7. doi: 10.1016/s0731-7085(03)00237-1.
The effect of temperature and relative atmospheric humidity on the stability of the crystalline form of cefuroxime axetil (CFA) in solid state was investigated. CFA is a mixture of diastereomers A and B. Changes in the concentration of the two diastereomers (A and B) of CFA were recorded by means of HPLC with UV detection. The degradation of diastereomers of CFA occurring at 0% relative humidity (RH) of the ambient air is a reversible first order reaction, while that occurring in humid air (RH>50%) is an autocatalytic first order reaction relative to substrate concentration. Although it has been found, that diastereomer B is the more stable isomer, humidity has a stronger effect on this very diastereomer.
研究了温度和相对大气湿度对固态头孢呋辛酯（CFA）晶型稳定性的影响。CFA是非对映异构体A和B的混合物。通过带紫外检测的高效液相色谱法记录CFA两种非对映异构体（A和B）浓度的变化。在环境空气相对湿度（RH）为0%时发生的CFA非对映异构体降解是一个可逆的一级反应，而在潮湿空气中（RH>50%）发生的降解是相对于底物浓度的自催化一级反应。尽管已发现非对映异构体B是更稳定的异构体，但湿度对该非对映异构体的影响更强。
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