Vavilov M P, Belopol'skiĭ A A, Apollonova L A, Nazarova E K
Biull Eksp Biol Med. 1992 Nov;114(11):521-3.
PAN and leukocytolysis were measured in dog blood placed in hypo- and hypertonic solutions of glycerin and glucose (1:10). It was found that leukocytolytic activity of the substances depends on equimolar concentrations of nonelectrolytes. It is more pronounced in hypo- than in hypertonic conditions. Glycerin is 3-5-times more active than glucose. In concentrations 2.0 M for glycerin and 0.5 M for glucose leukocytolysis is less active. Mononuclears are more resistant than neutrophils in strong solutions. PAN increased by 11-16% in hypotonic solutions. Strong glycerin solutions reduce PAN less than glucose which stimulates the digestive activity. The results can be of use in specific leukolysis tests to diagnose drug allergy.
在置于甘油和葡萄糖（1:10）的低渗和高渗溶液中的犬血中测量了PAN和白细胞溶解情况。发现这些物质的白细胞溶解活性取决于非电解质的等摩尔浓度。在低渗条件下比高渗条件下更明显。甘油的活性比葡萄糖高3至5倍。在甘油浓度为2.0 M和葡萄糖浓度为0.5 M时，白细胞溶解活性较低。在强溶液中，单核细胞比中性粒细胞更具抗性。在低渗溶液中PAN增加了11%至16%。强甘油溶液对PAN的降低作用小于葡萄糖，而葡萄糖会刺激消化活性。这些结果可用于特定的白细胞溶解试验以诊断药物过敏。
