Winkler Eyal, Bar-Meir Eran, Regev Eli, Haik Josef, Tamir Jeremy, Orenstein Arie
Plastic and Reconstructive Surgery Department, Sheba Medical Center, Tel Hashomer.
Harefuah. 2003 Jul;142(7):536-40, 565.
Silicone breast implants are used for breast reconstruction and breast augmentation. In the late 80's anecdotal literature describing a possible connection between silicone gel filled breast implants and autoimmune disease accumulated. Emerging concern about the safety of silicone gel implants had led the FDA to restrict their use. The continued use of the implants in postmastectomy reconstruction was allowed, as was their use in a small number of breast augmentation patients who were willing to enroll in long-term studies. In recent years, large meta-analyses established the fact that there is no association between silicone gel breast implants and autoimmune disease. We review the current literature, emphasizing the most important epidemiologic studies.
硅胶乳房植入物用于乳房重建和隆胸。在80年代后期，描述填充硅胶凝胶的乳房植入物与自身免疫性疾病之间可能存在联系的轶事文献不断积累。对硅胶凝胶植入物安全性的日益关注导致美国食品药品监督管理局（FDA）限制其使用。乳房切除术后重建中植入物的继续使用被允许，少数愿意参加长期研究的隆胸患者使用植入物也被允许。近年来，大型荟萃分析证实了硅胶凝胶乳房植入物与自身免疫性疾病之间没有关联这一事实。我们回顾当前文献，重点介绍最重要的流行病学研究。
