Lo David, Hilbush Brian, O'Mahony Daniel, Sutcliffe J Gregor
Digital Gene Technologies, Inc., La Jolla, CA 92037, USA.
Expert Rev Vaccines. 2002 Jun;1(1):95-100. doi: 10.1586/14760584.1.1.95.
Ongoing development of vaccines is limited by the techniques used to identify routes to immunization. Using open system gene expression profiling, researchers can now directly identify receptors used by M-cells in the transport of antigens to the mucosal immune system. These receptors will be ideal for targeted delivery of new synthetic vaccines. In addition, gene expression profiling will provide important new information on the biology of the M-cell and mucosal immune mechanisms.
疫苗的持续研发受到用于确定免疫途径的技术的限制。利用开放系统基因表达谱分析，研究人员现在可以直接识别M细胞在将抗原转运至黏膜免疫系统过程中所使用的受体。这些受体将是新型合成疫苗靶向递送的理想选择。此外，基因表达谱分析将为M细胞生物学和黏膜免疫机制提供重要的新信息。
