Capucchio M T, Lotti D, Cornaglia E, Valenza F, Schiffer D
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Turin, Grugliasco, Italy.
Clin Neuropathol. 2003 Jul-Aug;22(4):176-9.
A 13-year-old, male German Shepherd dog was euthanasized for a frontal temporal mass revealed by the MRI. The histological examination showed a proliferation composed of small round undifferentiated cells arranged in sheets or nests and sometimes in pseudorosettes interrupted by hypocellular zones of fibrovascular stroma. Immunohistochemical studies revealed the expression of neuroblastic epitopes. The presented neoplasm has many histological and immunohistochemical features in common with the group of olfactory neuroblastomas reported in man, so it could be classified as primitive neuroectodermal tumor with neuronal differentiation.
一只13岁的雄性德国牧羊犬因MRI显示额颞部肿块而被安乐死。组织学检查显示肿瘤由小圆形未分化细胞组成，这些细胞呈片状或巢状排列，有时形成假菊形团，被纤维血管间质的细胞稀少区域中断。免疫组化研究显示神经母细胞表位的表达。该肿瘤在组织学和免疫组化特征上与人类报道的嗅神经母细胞瘤组有许多共同之处，因此可归类为具有神经元分化的原始神经外胚层肿瘤。
