Linial M L, Eastman S W
Division of Basic Sciences A3-015, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA.
Curr Top Microbiol Immunol. 2003;277:89-110. doi: 10.1007/978-3-642-55701-9_4.
Foamy virus (FV) replication is distinct from that of all other retroviruses in many respects, including viral assembly. In fact, the viral assembly pathway is rather similar to that of hepadnaviruses such as hepatitis B virus. Foamy virus Gag does not contain landmark retroviral assembly domains such as the major homology region, Cys-His boxes, or a defined M domain. Like hepadnaviruses, the FV Gag protein is not cleaved and contains arginine-rich regions at the carboxyl terminus. In addition, egress of FV particles requires presence of the envelope glycoproteins. Finally, the cis-acting sequences in the FV genome required for genome incorporation, although poorly defined, differ in location from other retroviruses.
泡沫病毒（FV）的复制在许多方面，包括病毒组装，都与所有其他逆转录病毒不同。事实上，病毒组装途径与乙肝病毒等嗜肝DNA病毒颇为相似。泡沫病毒Gag不包含标志性的逆转录病毒组装结构域，如主要同源区域、半胱氨酸-组氨酸盒或特定的M结构域。与嗜肝DNA病毒一样，FV Gag蛋白不会被切割，且在羧基末端含有富含精氨酸的区域。此外，FV颗粒的释放需要包膜糖蛋白的存在。最后，尽管FV基因组中用于基因组整合的顺式作用序列定义不明确，但其位置与其他逆转录病毒不同。
