Lindman Anja Schou, Müller Hanne, Seljeflot Ingebjørg, Prydz Hans, Veierød Marit, Pedersen Jan I
University College of Akershus, Bekkestua, Norway.
Br J Nutr. 2003 Aug;90(2):329-36. doi: 10.1079/bjn2003911.
Dietary fat influences plasma levels of coagulation factor VII (FVII) and serum phospholipids (PL). It is, however, unknown if the fat-mediated changes in FVII are linked to PL. The present study aimed to investigate the effects of dietary fat on fasting and postprandial levels of activated FVII (FVIIa), FVII coagulant activity (FVIIc), FVII protein (FVIIag) and choline-containing PL (PC). In a randomized single-blinded crossover-designed study a high-fat diet (HSAFA), a low-fat diet (LSAFA), both rich in saturated fatty acids, and a high-fat diet rich in unsaturated fatty acids (HUFA) were consumed for 3 weeks. Twenty-five healthy females, in which postprandial responses were studied in a subset of twelve, were included. The HSAFA diet resulted in higher levels of fasting FVIIa and PC compared with the LSAFA and the HUFA diets (all comparisons P< or =0.01). The fasting PC levels after the LSAFA diet were also higher than after the HUFA diet (P<0.001). Postprandial levels of FVIIa and PC were highest on the HSAFA diet and different from LSAFA and HUFA (all comparisons P< or =0.05). Postprandial FVIIa was higher on the HUFA compared with the LSAFA diet (P<0.03), whereas the HUFA diet resulted in lower postprandial levels of PC than the LSAFA diet (P<0.001). Significant correlations between fasting levels of PC and FVIIc were found on all diets, whereas FVIIag was correlated to PC on the HSAFA and HUFA diet. The present results indicate that dietary fat, both quality and quantity, influences fasting and postprandial levels of FVIIa and PC. Although significant associations between fasting FVII and PC levels were found, our results do not support the assumption that postprandial FVII activation is linked to serum PC.
膳食脂肪会影响凝血因子VII（FVII）的血浆水平和血清磷脂（PL）。然而，FVII中由脂肪介导的变化是否与PL有关尚不清楚。本研究旨在调查膳食脂肪对活化FVII（FVIIa）、FVII凝血活性（FVIIc）、FVII蛋白（FVIIag）和含胆碱PL（PC）的空腹及餐后水平的影响。在一项随机单盲交叉设计研究中，受试者食用富含饱和脂肪酸的高脂饮食（HSAFA）、低脂饮食（LSAFA）以及富含不饱和脂肪酸的高脂饮食（HUFA）3周。纳入了25名健康女性，其中12名的餐后反应得到研究。与LSAFA和HUFA饮食相比，HSAFA饮食导致空腹FVIIa和PC水平更高（所有比较P≤0.01）。LSAFA饮食后的空腹PC水平也高于HUFA饮食后（P<0.001）。HSAFA饮食时FVIIa和PC的餐后水平最高，且与LSAFA和HUFA不同（所有比较P≤0.05）。与LSAFA饮食相比，HUFA饮食时餐后FVIIa更高（P<0.03），而HUFA饮食导致的餐后PC水平低于LSAFA饮食（P<0.001）。在所有饮食中均发现PC的空腹水平与FVIIc之间存在显著相关性，而在HSAFA和HUFA饮食中FVIIag与PC相关。目前的结果表明，膳食脂肪的质量和数量都会影响FVIIa和PC的空腹及餐后水平。虽然发现空腹FVII与PC水平之间存在显著关联，但我们的结果并不支持餐后FVII激活与血清PC有关这一假设。
