Fleming D R, Doukas M A
University of Kentucky, Division of Hematology/Oncology, Markey Cancer Center, Lexington 40536-0084.
Leuk Lymphoma. 1992 Nov;8(4-5):315-8. doi: 10.3109/10428199209051009.
Acute tumor lysis syndrome (ATLS) represents one of the most urgent of all oncologic treatment related complications. This is due not only to its broad impact on organ dysfunction, but also to its relative ease of prevention and treatment when aware of its potential threat. Despite anecdotal experiences of ATLS in settings outside the use of chemotherapy, the majority of patients susceptible to ATLS can be predicted using clinical as well as laboratory parameters and prophylaxis can prevent this potentially lethal consequence of otherwise successful cancer therapeutics. This review article will attempt to bring the critical aspects involving ATLS together in order to delineate the pathophysiology as well as treatment of this generally avoidable entity.
急性肿瘤溶解综合征（ATLS）是所有肿瘤治疗相关并发症中最为紧急的情况之一。这不仅是因为它对器官功能障碍有广泛影响，还因为当意识到其潜在威胁时，相对容易预防和治疗。尽管在化疗以外的情况下也有ATLS的零星病例报道，但大多数易患ATLS的患者可以通过临床及实验室参数进行预测，并且预防性治疗可以防止这种原本成功的癌症治疗可能导致的致命后果。这篇综述文章将试图把涉及ATLS的关键方面汇总起来，以阐明这种通常可避免情况的病理生理学及治疗方法。
