Thamotharan S, Parthasarathi V, Gupta P, Jindal D P, Piplani P, Linden Anthony
Department of Physics, Bharathidasan University, Tiruchirappalli 620 024, India.
Acta Crystallogr C. 2003 Aug;59(Pt 8):o467-9. doi: 10.1107/s0108270103013258. Epub 2003 Jul 22.
The title compounds, 4-(2-naphthyloxymethylcarbonyl)morpholine, C(16)H(17)NO(3), (I), and 4-methyl-1-(2-naphthyloxymethylcarbonyl)piperazine, C(17)H(20)N(2)O(2), (II), are potential antiamnesics. The morpholine ring in (I) and the piperazine ring in (II) adopt chair conformations. In (I), the molecules are linked by weak intermolecular C-H.O interactions into chains that have a graph-set motif of C(10), while in (II), the molecules are linked by weak intermolecular C-H.O interactions that generate two C(7) graph-set motifs. The dihedral angle between the naphthalene moiety and the best plane through the morpholine ring is 20.62 (4) degrees in (I), while the naphthalene moiety is oriented nearly perpendicular to the mean plane of the piperazine ring in (II).
标题化合物4-(2-萘氧基甲基羰基)吗啉，C(16)H(17)NO(3)，(I)，和4-甲基-1-(2-萘氧基甲基羰基)哌嗪，C(17)H(20)N(2)O(2)，(II)，是潜在的抗遗忘剂。(I)中的吗啉环和(II)中的哌嗪环均呈椅式构象。在(I)中，分子通过弱分子间C-H…O相互作用连接成具有C(10)图形集 motif的链，而在(II)中，分子通过弱分子间C-H…O相互作用连接，产生两个C(7)图形集 motif。在(I)中，萘部分与通过吗啉环的最佳平面之间的二面角为20.62(4)°，而在(II)中，萘部分几乎垂直于哌嗪环的平均平面。
