Fradet Gérard, Robin-Le Nechet Anne, Huguenin Hélène, Chiffoleau Anne
Service de Médecine Interne, Centre Hospitalier Général, Boulevard Renaud, BP 159, 85407 Luçon Cedex.
Ann Med Interne (Paris). 2003 May;154(3):181-2.
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) which acts via specific inhibition of cyclooxygenase-2 (synthesis of prostaglandins mediating pathological inflammation) but which preserves the homeostatic action of cyclooxygenase-1. The efficacy of celecoxib is similar to that of classical NSAIDs and its tolerance is comparable with that of placebo. We nevertheless observed one patient with hypersensitivity to celecoxib who developed fever, toxic skin reaction, and liver involvement.
塞来昔布是一种非甾体抗炎药（NSAID），通过特异性抑制环氧化酶-2（介导病理性炎症的前列腺素合成）发挥作用，但保留了环氧化酶-1的稳态作用。塞来昔布的疗效与传统NSAIDs相似，其耐受性与安慰剂相当。然而，我们观察到一名对塞来昔布过敏的患者出现了发热、中毒性皮肤反应和肝脏受累。
