Velho G
INSERM U. 561, Hôpital Saint-Vincent-de-Paul F-75674 PARIS Cedex 14.
Ann Endocrinol (Paris). 2003 Jun;64(3 Suppl):S17-21.
It is important to consider in clinical practice the diagnosis of MODY and to characterise the MODY sub-type. Indeed, evolution, clinical consequences and treatment of these forms of diabetes will be different according to the genetic origin of MODY. The main characteristics and consequences in clinical practice of these genetic abnormalities are briefly described, with a particular emphasis on the two most frequent sub-types, MODY-2 and MODY-3, caused by mutations of the enzyme glucokinase and of the transcription factor hepatocyte nuclear factor-1 alpha (HNF-1a) respectively.
