Photodynamic inhibition of infection caused by drug-resistant variants of herpes simplex virus type I.
作者信息
Kvacheva Z B, Shukanova N A, Votyakov V I, Lobanok E S, Vorobei A V, Nikolaeva S N
机构信息
State Institute of Epidemiology and Microbiology, Ministry of Health of Belarus Republic, Minsk.
出版信息
Bull Exp Biol Med. 2003 Apr;135(4):384-7. doi: 10.1023/a:1024625201337.
PMID:12910315
Abstract
Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentration 1 microM, illumination dose 32.5-65.0 kJ/m(2), exposure at early stages of infection). Infected cells actively bind the photosensitizer, which explains their selective photodamage.
摘要
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