Willis Jace A, Cheburkanov Vsevolod, Kassab Giulia, Soares Jennifer M, Blanco Kate C, Bagnato Vanderlei S, Yakovlev Vladislav V
Department of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil.
Appl Phys Rev. 2021 Jun;8(2):021315. doi: 10.1063/5.0044713.
Antibiotic-resistant bacteria, which are growing at a frightening rate worldwide, has put the world on a long-standing alert. The COVID-19 health crisis reinforced the pressing need to address a fast-developing pandemic. To mitigate these health emergencies and prevent economic collapse, cheap, practical, and easily applicable infection control techniques are essential worldwide. Application of light in the form of photodynamic action on microorganisms and viruses has been growing and is now successfully applied in several areas. The efficacy of this approach has been demonstrated in the fight against viruses, prompting additional efforts to advance the technique, including safety use protocols. In particular, its application to suppress respiratory tract infections and to provide decontamination of fluids, such as blood plasma and others, can become an inexpensive alternative strategy in the fight against viral and bacterial infections. Diverse early treatment methods based on photodynamic action enable an accelerated response to emerging threats prior to the availability of preventative drugs. In this review, we evaluate a vast number of photodynamic demonstrations and first-principle proofs carried out on viral control, revealing its potential and encouraging its rapid development toward safe clinical practice. This review highlights the main research trends and, as a futuristic exercise, anticipates potential situations where photodynamic treatment can provide a readily available solution.
抗生素耐药细菌在全球范围内正以惊人的速度增长，这使全球长期处于警戒状态。新冠疫情健康危机强化了应对快速发展的大流行病的迫切需求。为缓解这些健康紧急情况并防止经济崩溃，全球急需廉价、实用且易于应用的感染控制技术。以光动力作用形式对微生物和病毒施加光照的应用一直在增加，目前已成功应用于多个领域。这种方法在对抗病毒方面的功效已得到证明，促使人们进一步努力推进该技术，包括安全使用方案。特别是，其应用于抑制呼吸道感染以及对诸如血浆等液体进行消毒，可能成为对抗病毒和细菌感染的一种廉价替代策略。基于光动力作用的多种早期治疗方法能够在预防性药物可用之前对新出现的威胁做出快速反应。在本综述中，我们评估了大量关于病毒控制的光动力演示和第一性原理证明，揭示了其潜力并鼓励其朝着安全的临床实践快速发展。本综述突出了主要研究趋势，并作为一种前瞻性探讨，预测了光动力治疗能够提供现成解决方案的潜在情形。
