Louryan S, Vanmuylder N, Résimont S
Laboratoire d'Anatomie et Embryologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium.
Surg Radiol Anat. 2003 Jul-Aug;25(3-4):342-4. doi: 10.1007/s00276-003-0127-9. Epub 2003 Aug 9.
A case report of unilateral congenital stapes misplacement revealed by computed tomography is presented. In addition to this malformation, the malleus was synostosed to the middle ear roof. This kind of stapes ectopia has not been described previously. We have analyzed the malformative pattern in the light of normal and teratologic development of the stapes. In a teratologic model in which retinoic acid is administered to pregnant mice, we have observed an ectopic stapes primordium independent of the otic capsule. We discuss the possible pathogenesis of this abnormality in terms of the genetic events of middle ear development, which can be perturbed by retinoic acid administration.
本文报告一例通过计算机断层扫描发现的单侧先天性镫骨错位病例。除了这种畸形外，锤骨与中耳顶壁融合。这种镫骨异位此前尚未见报道。我们根据镫骨的正常和致畸发育情况分析了畸形模式。在给怀孕小鼠注射视黄酸的致畸模型中，我们观察到一个独立于耳囊的异位镫骨原基。我们根据中耳发育的遗传事件讨论了这种异常的可能发病机制，视黄酸给药可能会干扰这些遗传事件。
