Shen Tao, Bai Huai, Liu Bingwen, Liu Yu, Zhang Zuhui, Deng Zuyue
Apolipoprotein Research Unit, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):405-8.
To investigate the changes of plasma haemostatic and fibrinolytic activities and their relationship to serum lipids and apolipoproteins levels in endogenous hypertriglyceridemic patients.
We determined the plasma prothrombin time(PT), activated partial thromplastin time(APTT), activity of tissue-type plasminogen activator(t-PA), activity of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen(Fg) level of 24 endogenous hyper-triglyceridemic patients and 34 healthy controls, and observed their relationship to serum lipids and apolipoproteins.
The PT and APTT of patients with hypertriglyceridemia were obviously shorter than those of control subjects (P < 0.01, P < 0.05); PAI-1 of patients was significant higher than that of control group (P < 0.01); there was no statistically significant difference in t-PAI-1: a between the control subjects and the hypertriglyceridemic patients; the levels of Fg in patients was 27% higher than that in healthy control (P < 0.01). The correlation analysis indicated that PT was significantly associated with the levels of plasma HDL-C (r = 0.445, P < 0.01), and inversely associated with the levels of plasma TG, apoC III, BG and BMI (r = -0.294, -0.320, -0.282, -0.272, P < 0.05); APTT was negatively correlated with serum TG and apoC III levels (r = -0.345, -0.320, P < 0.05); t-PA was negatively correlated with BG levels (r = -0.336, P < 0.01). PAI-1 and Fg levels were strongly correlated with serum TG, apoC II, C III and E levels (r = 0.400, 0.408, 0.497, 0.454, P < 0.01 and r = 0.642, 0.581, 0.673, 0.304, P < 0.01, respectively), and negatively correlated with HDL-C (r = -0.366, -0.524, P < 0.01).
Increasing of coagulating activity and decreasing of fibrinolytic activity in hypertriglyceridemic patients were significantly associated with serum lipids and apolipoproteins levels.
探讨内源性高甘油三酯血症患者血浆止血和纤溶活性的变化及其与血脂和载脂蛋白水平的关系。
我们测定了24例内源性高甘油三酯血症患者和34例健康对照者的血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、组织型纤溶酶原激活物（t-PA）活性、纤溶酶原激活物抑制剂-1（PAI-1）活性和纤维蛋白原（Fg）水平，并观察了它们与血脂和载脂蛋白的关系。
高甘油三酯血症患者的PT和APTT明显短于对照组（P<0.01，P<0.05）；患者的PAI-1显著高于对照组（P<0.01）；对照组与高甘油三酯血症患者之间的t-PA:a无统计学差异；患者的Fg水平比健康对照组高27%（P<0.01）。相关性分析表明，PT与血浆高密度脂蛋白胆固醇（HDL-C）水平显著相关（r=0.445，P<0.01），与血浆甘油三酯（TG）、载脂蛋白C III（apoC III）、血糖（BG）和体重指数（BMI）水平呈负相关（r=-0.294、-0.320、-0.282、-0.272，P<0.05）；APTT与血清TG和apoC III水平呈负相关（r=-0.345、-0.320，P<0.05）；t-PA与BG水平呈负相关（r=-0.336，P<0.01）。PAI-1和Fg水平与血清TG、apoC II、C III和E水平密切相关（r分别为0.400、0.408、0.497、0.454，P<0.01和r=0.642、0.581、0.673、0.304，P<0.01），与HDL-C呈负相关（r=-0.366、-0.524，P<0.01）。
高甘油三酯血症患者凝血活性增加和纤溶活性降低与血脂和载脂蛋白水平显著相关。
