[成都汉族妊娠期肝内胆汁淤积症家系中人类白细胞抗原-DPA1基因多态性分布]
[Human leucocyte antigen-DPA1 polymorphism distribution in Chengdu Chinese families with intrahepatic cholestasis of pregnancy].
作者信息
Zhang Li, Liu Shuyun, Chen Qiang, Yang Xuemei, Chen Xianhui
机构信息
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):530-2.
OBJECTIVE
To investigate the relationship between human leucocyte antigen (HLA)-DPA1 region gene polymorphism and intrahepatic cholestasis of pregnancy (ICP).
METHODS
The HLA-DPA1 alleles of 25 ICP families and 25 normal control group families were analysed by polymerase chain reaction-sequence specific primers(PCR-SSP) method.
RESULTS
The analysis of the frequencies and feto-maternal or couples sharing of the DPA1 alleles showed that no statistically significant difference was observed between the two study groups.
CONCLUSION
It is unlikely that an HLA-DPA1 allele is primarily associated with susceptibility or resistance to ICP.
目的
探讨人类白细胞抗原（HLA）-DPA1区域基因多态性与妊娠期肝内胆汁淤积症（ICP）的关系。
方法
采用聚合酶链反应-序列特异性引物（PCR-SSP）法分析25个ICP家族和25个正常对照组家族的HLA-DPA1等位基因。
结果
对DPA1等位基因的频率以及胎儿与母亲或夫妻间共享情况的分析表明，两个研究组之间未观察到统计学上的显著差异。
结论
HLA-DPA1等位基因不太可能是主要与ICP易感性或抗性相关的基因。
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