Cizmáriková R, Gvozdjaková A, Kucharská J
Katedra anorganickej a organickej chémie Farmaceutickej fakulty, Univerzity Komenského, Bratislava.
Cesk Farm. 1992 Sep;41(6):191-3.
Concentrations ranging from 1-9 x 10(-7) mol.dm-3 were employed for in vitro studies. Under the selected experimental conditions, both agents markedly decreased the stimulated consumption of oxygen by the cardiac muscle mitochondria in the condition S3, the rate of the formation of energy by mitochondria as well as the respiratory control index. The coefficient of oxidative phosphorylation was not markedly changed due to the effect of the added agents. The results of the present paper suggest possible integration of the cardiac muscle mitochondria in the oxidative metabolism of the potential beta-adrenolytic agents FA33 and FP33, which requires further in vivo studies.
在体外研究中使用了浓度范围为1 - 9×10⁻⁷摩尔·分米⁻³的物质。在选定的实验条件下，两种药物均显著降低了S3条件下心肌线粒体刺激的氧气消耗、线粒体产生能量的速率以及呼吸控制指数。由于添加药物的作用，氧化磷酸化系数没有明显变化。本文结果表明，潜在的β - 肾上腺素能阻断剂FA33和FP33可能参与心肌线粒体的氧化代谢，这需要进一步的体内研究。
