Davis C, Fischer J, Ley K, Sarembock I J
Department of Medicine, Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA 22908-0158, USA.
J Thromb Haemost. 2003 Aug;1(8):1699-709. doi: 10.1046/j.1538-7836.2003.00292.x.
Inflammation plays a critical role in the vascular response to injury. In particular, mechanical injury using techniques such as balloon angioplasty and stenting results in complex inflammatory reactions which influence proliferation of vessel wall constituents such as endothelial cells, smooth muscle cells, and extracellular matrix proteins. Inflammatory cells are recruited to the injured vessel wall initially as a reparative mechanism; however, these same inflammatory processes are also pivotal in the development of restenotic lesions. Leukocytes serve as the primary inflammatory cells but we now know that platelets produce a number of important inflammatory mediators. This review describes the mechanisms that regulate endothelial cell migration, smooth muscle cell activation, and extracellular matrix protein production, all of which are key components in the inflammatory response to vascular injury.
炎症在血管对损伤的反应中起关键作用。特别是，使用球囊血管成形术和支架置入术等技术造成的机械损伤会引发复杂的炎症反应，这些反应会影响血管壁成分（如内皮细胞、平滑肌细胞和细胞外基质蛋白）的增殖。炎症细胞最初作为一种修复机制被募集到受损的血管壁；然而，这些相同的炎症过程在再狭窄病变的发展中也起着关键作用。白细胞是主要的炎症细胞，但我们现在知道血小板会产生许多重要的炎症介质。这篇综述描述了调节内皮细胞迁移、平滑肌细胞活化和细胞外基质蛋白产生的机制，所有这些都是血管损伤炎症反应的关键组成部分。
