Sindos M, Ndisang D, Pisal N, Chow C, Deery A, Singer A, Latchman D
Institute of Child Health, University College London, UK.
Int J Gynecol Cancer. 2003 Jul-Aug;13(4):515-7. doi: 10.1046/j.1525-1438.2003.13303.x.
Measurement of the Brn-3a cellular transcription factor in cervical smears from women referred for colposcopy may improve the detection of underlying cervical neoplasia. In those women referred with persisting borderline or mildly dyskaryotic smears, those who had histologically proven underlying CIN II/III, had statistically significant higher Brn-3a levels than those with a similar smear but histologically shown to have HPV, CIN I, or no cervical abnormality. These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.
对因阴道镜检查而转诊的女性宫颈涂片进行Brn-3a细胞转录因子检测，可能会提高对潜在宫颈肿瘤的检测率。在那些因宫颈涂片持续处于临界状态或轻度核异质而转诊的女性中，经组织学证实存在CIN II/III的女性，其Brn-3a水平在统计学上显著高于涂片情况相似但经组织学显示患有HPV、CIN I或无宫颈异常的女性。这些结果表明，Brn-3a在不久的将来可能在改善宫颈癌筛查方面发挥重要作用。
