Zhang M M, Jiang B
People's Hospital of Beijing Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1992 Jul;27(4):224-6, 250-1.
Sixty cases of pregnancy with thrombocytopenia were analyzed. Bleeding syndrome was found in 36 patients during pregnancy, with 7 cases suffering from massive hemorrhage during delivery and a postpartum hemorrhage rate of 11.7%. There was a negative correlation between the platelet level and the amount of bleeding during gestation and delivery. We suggest that cortico steroid is necessary with a platelet count less than 50 x 10(9)/L in the middle or late trimester of pregnancy to reduce the bleeding tendency during delivery, as well as the incidence of thrombocytopenia in the newborn infant use of excessive platelet transfusion is not encouraged, since it implicates an increase in antibody-induction (PAIG) and probability of C type hepatitis in the recipient. Platelet transfusion should be reserved only for the treatment of serious hemorrhage. There were 53 newborn infants, 7 of whom (13.2%) suffered from thrombocytopenia, with a mortality of 1.9% (7/53) during the perinatal.
对60例血小板减少症孕妇进行了分析。36例患者在孕期出现出血综合征,7例在分娩时发生大出血,产后出血率为11.7%。血小板水平与妊娠及分娩期间的出血量呈负相关。我们建议,在妊娠中晚期血小板计数低于50×10⁹/L时,有必要使用皮质类固醇以减少分娩时的出血倾向,以及新生儿血小板减少症的发生率。不鼓励过度使用血小板输血,因为这会增加受血者抗体诱导(PAIG)和丙型肝炎的发生概率。血小板输血仅应保留用于治疗严重出血。共有53例新生儿,其中7例(13.2%)患有血小板减少症,围产期死亡率为1.9%(7/53)。