[酶联免疫吸附测定法检测重症肌无力患者血清中的抗细丝蛋白抗体]

[ELISA for detection of anti-filamin antibody in sera from patient with myasthenia gravis].

作者信息

Lin H

机构信息

Fuzhow General Hospital, Nanjin Command, PLA, Fujian.

出版信息

Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1992 Oct;25(5):281-3, 316-7.

PMID:1291249

Abstract

The activity of anti-filamin antibody was determined in sera from 128 patients with myasthenia gravis (MG) by enzyme-linked immunosorbent assay (ELISA). The positive rate was 77.34%. No correlation was observed between anti-F-ab and nAchRab and CAEab. The antibody-absorbtion test were positive. The result demonstrated that anti-F-ab may play some role in the pathology of MG. The clinical use of ELISA for detection of anti-F-ab may help to diagnose MG.

摘要

采用酶联免疫吸附测定（ELISA）法检测了128例重症肌无力（MG）患者血清中的抗细丝蛋白抗体活性。阳性率为77.34%。未观察到抗F-ab与抗烟碱型乙酰胆碱受体抗体（nAchRab）及抗横纹肌抗体（CAEab）之间存在相关性。抗体吸收试验呈阳性。结果表明，抗F-ab可能在MG的病理过程中发挥一定作用。ELISA法临床检测抗F-ab可能有助于MG的诊断。