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[通过定量药物脑电图预测氟哌啶醇对精神分裂症患者的影响]

[Predicting the effects of haloperidol on schizophrenics by quantitative pharmaco-EEG].

作者信息

Zhang X L

机构信息

Institute of Mental Health, Beijing Medical University.

出版信息

Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1992 Oct;25(5):300-2, 318.

PMID:1291253
Abstract

In order to predict the short-term-outcome of schizophrenics under the treatment of haloperidol, changes of 15 schizophrenic subjects' EEG after 4 mg haloperidol oral intake were monitored with the method of QPEEG. The result of discriminate analysis showed that the more similar to typical EEG pattern of neuroleptics the patients showed, the better the patients responded to haloperidol treatment. Meanwhile, the haloperidol therapeutic mechanisms of brain electro-physiology and the electro-physiological characteristics of schizophrenics were also discussed.

摘要

为预测精神分裂症患者在服用氟哌啶醇治疗下的短期疗效,采用定量脑电图(QPEEG)方法监测了15例精神分裂症患者口服4毫克氟哌啶醇后脑电图的变化。判别分析结果显示,患者脑电图模式与典型抗精神病药物脑电图模式越相似,对氟哌啶醇治疗的反应就越好。同时,还探讨了氟哌啶醇的脑电生理治疗机制及精神分裂症患者的电生理特征。

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