细胞分化过程中的特异性蛋白质靶向：酿酒酵母交配过程中Fus1p的极化定位依赖于Chs5p。
Specific protein targeting during cell differentiation: polarized localization of Fus1p during mating depends on Chs5p in Saccharomyces cerevisiae.
作者信息
Santos Beatriz, Snyder Michael
机构信息
Molecular, Cellular, and Developmental Biology Department, Yale University, New Haven, Connecticut 06520-8103, USA.
出版信息
Eukaryot Cell. 2003 Aug;2(4):821-5. doi: 10.1128/EC.2.4.821-825.2003.
Abstract
In budding yeast, chs5 mutants are defective in chitin synthesis and cell fusion during mating. Chs5p is a late-Golgi protein required for the polarized transport of the chitin synthase Chs3p to the membrane. Here we show that Chs5p is also essential for the polarized targeting of Fus1p, but not of other cell fusion proteins, to the membrane during mating.
摘要
在出芽酵母中，chs5突变体在交配过程中的几丁质合成和细胞融合方面存在缺陷。Chs5p是一种晚期高尔基体蛋白，是几丁质合酶Chs3p向膜进行极化运输所必需的。我们在此表明，Chs5p对于交配过程中Fus1p而非其他细胞融合蛋白向膜的极化靶向定位也是必不可少的。
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本文引用的文献
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Yeast mating: getting close to membrane merger.酵母交配：接近膜融合
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Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae.Chs7p是一种参与内质网蛋白质输出控制的新蛋白质，它专门参与酿酒酵母中几丁质合成的调控。
J Cell Biol. 1999 Jun 14;145(6):1153-63. doi: 10.1083/jcb.145.6.1153.
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Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae.酿酒酵母中Chs6p介导的Chs3p从几丁质体到质膜的正向运输。
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CHS5, a gene involved in chitin synthesis and mating in Saccharomyces cerevisiae.CHS5，一个参与酿酒酵母几丁质合成与交配的基因。
Mol Cell Biol. 1997 May;17(5):2485-96. doi: 10.1128/MCB.17.5.2485.
10
Targeting of chitin synthase 3 to polarized growth sites in yeast requires Chs5p and Myo2p.在酵母中，将几丁质合酶3靶向极化生长位点需要Chs5p和Myo2p。
J Cell Biol. 1997 Jan 13;136(1):95-110. doi: 10.1083/jcb.136.1.95.
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