Santos Beatriz, Snyder Michael
Molecular, Cellular, and Developmental Biology Department, Yale University, New Haven, Connecticut 06520-8103, USA.
Eukaryot Cell. 2003 Aug;2(4):821-5. doi: 10.1128/EC.2.4.821-825.2003.
In budding yeast, chs5 mutants are defective in chitin synthesis and cell fusion during mating. Chs5p is a late-Golgi protein required for the polarized transport of the chitin synthase Chs3p to the membrane. Here we show that Chs5p is also essential for the polarized targeting of Fus1p, but not of other cell fusion proteins, to the membrane during mating.
在出芽酵母中，chs5突变体在交配过程中的几丁质合成和细胞融合方面存在缺陷。Chs5p是一种晚期高尔基体蛋白，是几丁质合酶Chs3p向膜进行极化运输所必需的。我们在此表明，Chs5p对于交配过程中Fus1p而非其他细胞融合蛋白向膜的极化靶向定位也是必不可少的。
