发育异常：难治性小儿颞叶癫痫的常见表现。
Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy.
作者信息
Porter B E, Judkins A R, Clancy R R, Duhaime A, Dlugos D J, Golden J A
机构信息
Pediatric Regional Epilepsy Program, Children's Hospital of Philadelphia, and Department of Pediatrics and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
出版信息
Neurology. 2003 Aug 12;61(3):365-8. doi: 10.1212/01.wnl.0000076487.28227.6e.
BACKGROUND
Risk factors for temporal lobe epilepsy (TLE) include history of CNS infection, family history of epilepsy, and history of febrile convulsions (FC). Pre-existing cortical dysplasia (CD) may also predispose to refractory TLE, independent of other risk factors for epilepsy.
METHODS
The authors reviewed the neuropathologic features of surgical tissue from temporal lobectomies of 33 pediatric patients with refractory TLE, with and without a history of epilepsy risk factors.
RESULTS
CD was found in 64% (21/33) of all patients with refractory TLE, including 73% (11/15) patients with a history of FC, 66% (2/3) patients with CNS infections, and 83% (5/6) patients with a family history of epilepsy. Disrupted cortical lamination, dystrophic and maloriented neurons, and balloon cells characterized the CD found in the temporal neocortex.
CONCLUSION
CD was seen in 21 of 33 surgical specimens from children with refractory TLE, including those with and without other epilepsy risk factors.
背景
颞叶癫痫（TLE）的危险因素包括中枢神经系统感染史、癫痫家族史和热性惊厥（FC）史。先前存在的皮质发育异常（CD）也可能导致难治性TLE，与其他癫痫危险因素无关。
方法
作者回顾了33例难治性TLE儿科患者颞叶切除术手术组织的神经病理学特征，这些患者有或没有癫痫危险因素史。
结果
在所有难治性TLE患者中，64%（21/33）发现有CD，其中有FC史的患者中73%（11/15）、有中枢神经系统感染的患者中66%（2/3）、有癫痫家族史的患者中83%（5/6）发现有CD。颞叶新皮质中发现的CD的特征为皮质分层紊乱、神经元营养不良和排列异常以及气球样细胞。
结论
在33例难治性TLE儿童的手术标本中，21例发现有CD，包括有和没有其他癫痫危险因素的患者。
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