具有天然产物的类胰岛素锌（II）配合物：2型糖尿病KK-Ay小鼠的体外评价及降血糖作用
Insulinomimetic zinc(II) complexes with natural products: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus.
作者信息
Kojima Yoshitane, Yoshikawa Yutaka, Ueda Eriko, Ueda Rie, Yamamoto Shuhei, Kumekawa Katsumi, Yanagihara Naohisa, Sakurai Hiromu
机构信息
Department of Chemistry, Graduate School of Science, Osaka City University, Osaka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2003 Aug;51(8):1006-8. doi: 10.1248/cpb.51.1006.
In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(-)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-A(y) mice with type 2 diabetes mellitus was observed by daily i.p. injections of a monomeric zinc(II) complex, Zn(qui)(2), for 13 d.
在肾上腺素处理的大鼠脂肪细胞中，发现锌（II）与三种天然产物（甜菜碱、L-乳酸和D-（-）-奎尼酸（qui））形成的配合物具有体外类胰岛素活性，表现为对游离脂肪酸释放的抑制作用。基于这些结果，通过每天腹腔注射单体锌（II）配合物Zn（qui）₂，持续13天，观察了其对2型糖尿病KK-A（y）小鼠的降血糖作用。
Zotero 插件