鉴定乳酸链球菌素Q，一种从日本一条河流中分离出的乳酸乳球菌61-14产生的新型天然乳酸链球菌素变体。
Identification of the lantibiotic nisin Q, a new natural nisin variant produced by Lactococcus lactis 61-14 isolated from a river in Japan.
作者信息
Zendo Takeshi, Fukao Masanori, Ueda Kyoko, Higuchi Tomoko, Nakayama Jiro, Sonomoto Kenji
机构信息
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
出版信息
Biosci Biotechnol Biochem. 2003 Jul;67(7):1616-9. doi: 10.1271/bbb.67.1616.
Lactococcus lactis 61-14 isolated from river water produced a bacteriocin active against a wide range of Gram-positive bacteria. N-terminal amino acid sequencing, mass spectral analysis of the purified bacteriocin, and genetic analysis using nisin-specific primers showed that the bacteriocin was a new natural nisin variant, termed nisin Q. Nisin Q and nisin A differ in four amino acids in the mature peptide and two in the leader sequence.
从河水中分离出的乳酸乳球菌61-14产生了一种对多种革兰氏阳性菌具有活性的细菌素。对纯化后的细菌素进行N端氨基酸测序、质谱分析，并使用乳酸链球菌素特异性引物进行遗传分析，结果表明该细菌素是一种新的天然乳酸链球菌素变体，命名为乳酸链球菌素Q。乳酸链球菌素Q和乳酸链球菌素A在成熟肽中有四个氨基酸不同，在前导序列中有两个氨基酸不同。
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