神经管缺陷中母体血清和羊水羟脯氨酸水平
Maternal serum and amniotic fluid hydroxyproline levels in neural tube defects.
作者信息
Ozyurt Hüseyin, Totan Aylin, Sahin Semsettin, Kilinç Cumhur, Söğüt Sadik, Akyol Omer
机构信息
Department of Biochemistry, Inönü University Medical Faculty, Malatya, Turkey.
出版信息
Fetal Diagn Ther. 2003 Sep-Oct;18(5):321-3. doi: 10.1159/000071973.
OBJECTIVE
The present study was aimed to evaluate the alterations of maternal serum and amniotic fluid OH- proline levels in neural tube defects (NTD).
METHODS
38 patients and 23 control subjects were selected from the patients followed up by the Departments of Genetics and Antenatal Care, Zekai Tahir Burak Women's Health, Education and Research Hospital. Amnion fluid and blood samples were synchronously obtained from NTD and control subjects. OH-proline levels were detected spectrophotometrically.
RESULTS
Amniotic fluid OH-proline levels were found to be increased in NTD patients compared to control subjects (p < 0.05). There was no statistically significant difference in serum OH-proline levels between the groups.
CONCLUSION
The results showed an increase in amniotic fluid OH-proline levels in NTD compared to the control group. It may be suggested that the increased OH-proline levels reflect increased collagen turnover in NTD patients. Indeed, amniotic fluid OH-proline levels may be a candidate as an additional diagnostic parameter in NTD.
目的
本研究旨在评估神经管缺陷（NTD）患者母血清和羊水羟脯氨酸水平的变化。
方法
从泽凯·塔希尔·布拉克妇女健康、教育与研究医院遗传学和产前保健科随访的患者中选取38例患者和23例对照者。同时从NTD患者和对照者中采集羊水和血液样本。采用分光光度法检测羟脯氨酸水平。
结果
发现NTD患者的羊水羟脯氨酸水平高于对照者（p < 0.05）。两组血清羟脯氨酸水平无统计学显著差异。
结论
结果显示，与对照组相比，NTD患者羊水羟脯氨酸水平升高。可能提示羟脯氨酸水平升高反映了NTD患者胶原周转增加。事实上，羊水羟脯氨酸水平可能作为NTD的一个额外诊断参数。
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