Lont A P, Horenblas S, Tanis P J, Gallee M P, van Tinteren H, Nieweg O E
Department of Urology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 21, 1066 CX Amsterdam, The Netherlands.
J Urol. 2003 Sep;170(3):783-6. doi: 10.1097/01.ju.0000081201.40365.75.
We evaluated the clinical outcome of clinically node negative penile carcinoma managed by surveillance or further diagnosed by dynamic sentinel node biopsy with subsequent resection of lymph node metastases.
From 1956 to 1994, 85 patients with primary T2-3N0M0 penile squamous cell carcinoma were treated with initial surveillance of the regional lymph nodes. From 1994 until 2001, 68 patients underwent dynamic sentinel node biopsy.
The 2 populations were similar in terms of patient age, clinical T stage, tumor grade, vascular invasion and infiltration depth. Disease specific 3-year survival in the surveillance and sentinel node groups was 79% and 91%, respectively (log rank test p = 0.04).
Early detection of lymph node metastases by dynamic sentinel node biopsy and subsequent resection in clinically node negative T2-3 penile carcinoma improves survival compared with a policy of surveillance.
我们评估了通过监测管理的临床淋巴结阴性阴茎癌的临床结局，或通过动态前哨淋巴结活检进一步诊断并随后切除淋巴结转移灶的临床结局。
1956年至1994年，85例原发性T2 - 3N0M0阴茎鳞状细胞癌患者接受了区域淋巴结的初始监测。1994年至2001年，68例患者接受了动态前哨淋巴结活检。
两组患者在年龄、临床T分期、肿瘤分级、血管侵犯和浸润深度方面相似。监测组和前哨淋巴结组的疾病特异性3年生存率分别为79%和91%（对数秩检验p = 0.04）。
与监测策略相比，通过动态前哨淋巴结活检早期发现临床淋巴结阴性T2 - 3阴茎癌的淋巴结转移并随后进行切除可提高生存率。
