Lannergard A, Friman G, Larsson A
Department of Medical Sciences, Infectious Diseases, Uppsala University Hospital, S-751 85 Uppsala, Sweden.
J Urol. 2003 Sep;170(3):804-6. doi: 10.1097/01.ju.0000082220.23903.1f.
We compared serum amyloid A (SAA) protein, C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha as inflammatory markers for pyelonephritis and cystitis.
SAA, CRP, IL-6 and TNF-alpha were determined in serum from 69 consecutive patients with acute pyelonephritis (37) and acute cystitis (32) on admission to an infectious disease clinic and on examination at a primary health care center, respectively. Healthy blood donors served as controls.
SAA showed a systemic inflammatory response in cystitis in 90% of patients compared with 23%, 42% and 0% for CRP, IL-6 and TNF-alpha, respectively. SAA and CRP had equally high efficiencies (0.96 and 0.94, respectively) for discriminating between pyelonephritis and cystitis while efficiencies for IL-6 (0.85) and TNF-alpha (0.91) were lower.
SAA is a sensitive systemic marker in cystitis but is still useful in detecting pyelonephritis.
我们比较了血清淀粉样蛋白A（SAA）、C反应蛋白（CRP）、白细胞介素（IL）-6和肿瘤坏死因子（TNF）-α作为肾盂肾炎和膀胱炎炎症标志物的情况。
分别在一家传染病诊所对69例连续的急性肾盂肾炎患者（37例）和急性膀胱炎患者（32例）入院时以及在初级保健中心检查时测定其血清中的SAA、CRP、IL-6和TNF-α。健康献血者作为对照。
90%的膀胱炎患者中SAA呈现全身炎症反应，而CRP、IL-6和TNF-α的这一比例分别为23%、42%和0%。SAA和CRP在区分肾盂肾炎和膀胱炎方面具有同样高的效率（分别为0.96和0.94），而IL-6（0.85）和TNF-α（0.91）的效率较低。
SAA是膀胱炎中一种敏感的全身标志物，但在检测肾盂肾炎方面仍然有用。
