Croitoru Claudia M, Mooney Julia E, Luna Mario A
Department of Pathology, University of Texas Medical School, Houston, 77030, USA.
Ann Diagn Pathol. 2003 Aug;7(4):236-9. doi: 10.1016/s1092-9134(03)00052-2.
Primary sebaceous neoplasms of the salivary glands are extremely rare occurrences; furthermore, sebaceous lymphadenocarcinoma has only been reported in three patients. We report a case of sebaceous lymphadenocarcinoma arising in a lymphadenoma of the parotid gland. The patient was a 55-year-old man who presented with a parotid mass of 3 years' duration. Histologically, the lesion consisted of a sebaceous lymphadenoma with transition to a sebaceous carcinoma. The cytologic touch-preparation at the time of frozen section showed clusters of benign sebaceous cells in a rich lymphocytic background together with tridimensional clusters of malignant epithelial cells, strongly raising the suspicion of a malignant neoplasm arising in a benign sebaceous lesion. Malignant transformation of the sebaceous lymphadenoma, although rare, should be considered in enlarging, locally invasive parotid lesions, considering that clinical behavior and prognosis will be determined by the nature of the malignant component.
涎腺原发性皮脂腺肿瘤极为罕见；此外，皮脂腺淋巴腺癌仅在3例患者中被报道过。我们报告1例发生于腮腺淋巴结瘤的皮脂腺淋巴腺癌病例。患者为一名55岁男性，有一个持续3年的腮腺肿物。组织学上，病变由一个向皮脂腺癌转变的皮脂腺淋巴结瘤构成。冰冻切片时的细胞学印片显示，在丰富的淋巴细胞背景中有良性皮脂腺细胞团簇以及恶性上皮细胞的三维团簇，强烈提示在良性皮脂腺病变中发生了恶性肿瘤。皮脂腺淋巴结瘤的恶性转化虽然罕见，但对于不断增大、局部侵袭性的腮腺病变应予以考虑，因为临床行为和预后将由恶性成分的性质决定。
