Kosmala Wojciech, Spring Adam
Katedr i Klinika Kardiologii Akademii Medycznej we Wrocławiu.
Pol Merkur Lekarski. 2003 Mar;14(81):216-9.
Left ventricular hypertrophy, in particular concentric, accompanying hypertension is an independent risk factor of sudden death and other serious cardiovascular complications. It is still not clear how ANP and BNP are related to various types of left ventricular geometry and whether BNP is a better predictor of left ventricular hypertrophy and dysfunction than ANP. The aim of the study was estimation of plasma ANP and BNP levels in patients with hypertension in relation to the changes of left ventricular geometry. Investigations were carried out in 80 patients aged 52.5 +/- 12.6. In every patient plasma levels of ANP and BNP were estimated, blood pressure was measured and echocardiographic study was performed. Based on echocardiographic measurements every patient was classified into one of four left ventricular geometric patterns. It was found that in patients with left ventricular concentric hypertrophy plasma level of ANP and BNP was increased whereas in patients with concentric remodeling and eccentric hypertrophy only plasma level of ANP was elevated. In patients with concentric hypertrophy higher levels of ANP and BNP were found compared to patients with concentric remodeling and eccentric hypertrophy.
左心室肥厚，尤其是向心性肥厚，伴随高血压是猝死和其他严重心血管并发症的独立危险因素。目前仍不清楚心钠素（ANP）和脑钠肽（BNP）与各种类型的左心室几何形态有何关系，以及BNP是否比ANP更能预测左心室肥厚和功能障碍。本研究的目的是评估高血压患者血浆ANP和BNP水平与左心室几何形态变化的关系。对80名年龄为52.5±12.6岁的患者进行了调查。对每位患者测定血浆ANP和BNP水平，测量血压并进行超声心动图检查。根据超声心动图测量结果，将每位患者分为四种左心室几何形态模式之一。结果发现，左心室向心性肥厚患者的血浆ANP和BNP水平升高，而向心性重构和离心性肥厚患者仅血浆ANP水平升高。与向心性重构和离心性肥厚患者相比，向心性肥厚患者的ANP和BNP水平更高。
