Wang Zhiying, Zhang Qiang
Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2003 Jun 18;35(3):329-32.
To study the serum calcitonin(CT) levels in vivo after pulmonary delivery to rats and the effects of absorption enhancers.
Salmon calcitonin (sCT) solution was delivered by intramuscular injection or intratracheal administration to rats. The absorption of sCT was determined by radioimmunoassay method. Changes in serum drug levels after the pulmonary administration of sCT with various absorption enhancers or in different pH conditions were investigated.
Compared with intramuscular administration, the relative bioavailability of sCT solution (2 micrograms.kg-1) given by intratracheal route was 121.0%. Transpulmonary absorption of sCT solution, with some absorption enhancers (Brij78, sodium cholate, lecithin, chitosan and sodium caprylate) or under acidic conditions (pH3.0), was significantly greater than the values obtained in controls.
sCT solution showed higher bioavailability after pulmonary administration.
研究大鼠经肺部给药后体内血清降钙素（CT）水平及吸收促进剂的作用。
将鲑鱼降钙素（sCT）溶液通过肌肉注射或气管内给药至大鼠。采用放射免疫分析法测定sCT的吸收情况。研究了在使用各种吸收促进剂或不同pH条件下经肺部给予sCT后血清药物水平的变化。
与肌肉注射相比，气管内给予sCT溶液（2微克·千克-1）的相对生物利用度为121.0%。sCT溶液在使用某些吸收促进剂（Brij78、胆酸钠、卵磷脂、壳聚糖和辛酸钠）或在酸性条件（pH3.0）下的经肺吸收明显高于对照组。
sCT溶液经肺部给药后显示出更高的生物利用度。
