Schumm-Draeger P M, Encke A, Usadel K H
3, Medizinische Klinik, Abteilung Endokrinologie, Diabetologie und Angiologie, Klinikum München-Bogenhausen, Englschalkinger Strasse 77, 81925 München.
Internist (Berl). 2003 Apr;44(4):420-6, 429-32. doi: 10.1007/s00108-003-0879-7.
In summary the data of our study show: (1) Sonographically determined thyroid volume of patients with euthyroidism after surgery is found to be significantly lower with a combination therapy (iodide 150 microgram +Levothyroxine 75 microgram) compared to patients with iodide monotherapy (200 microgram). (2) Thyroid volume of patients with hypothyroidism after surgery is found to be significantly lower during a combination therapy (150 microgram iodide + 75 microgram L-thyroxine) compared to patients with a Levothyroxine monotherapy. (3) Patients with hypothyroidism and Levothyroxine monotherapy, however present with a significant increase of thyroid volume after surgery. (4) Urinary iodide excretion in the treatment groups with iodide or combination therapy increases significantly during therapy, however, patients with Levothyroxine monotherapy do not show changes. (5) Thyroid function is well stabilized in all treatment groups with adequate controls and adjustment of Levothyoxine dosage. There data clearly demonstrate that the combination therapy with Levothyoxine and iodide significantly improves prophylaxis of goiter recurrence.
总之，我们的研究数据表明：（1）与接受碘化钾单一疗法（200微克）的患者相比，接受联合疗法（碘化钾150微克+左甲状腺素75微克）的术后甲状腺功能正常患者的超声测定甲状腺体积显著更低。（2）与接受左甲状腺素单一疗法的患者相比，接受联合疗法（150微克碘化钾+75微克L-甲状腺素）的术后甲状腺功能减退患者的甲状腺体积显著更低。（3）然而，接受左甲状腺素单一疗法的甲状腺功能减退患者术后甲状腺体积显著增加。（4）接受碘化钾或联合疗法的治疗组患者在治疗期间尿碘排泄显著增加，然而，接受左甲状腺素单一疗法的患者未显示出变化。（5）在所有治疗组中，通过适当控制和调整左甲状腺素剂量，甲状腺功能得到良好稳定。这些数据清楚地表明，左甲状腺素和碘化钾联合疗法显著改善了甲状腺肿复发的预防。
