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通过STR多态性分析佛得角群岛人群的遗传分化。

Genetic differentiation of the Cabo Verde archipelago population analysed by STR polymorphisms.

作者信息

Fernandes A T, Velosa R, Jesus J, Carracedo A, Brehm A

机构信息

Human Genetics Laboratory, Centre of Macaronesian Studies, University of Madeira, Penteada, 9000 Funchal, Portugal.

出版信息

Ann Hum Genet. 2003 Jul;67(Pt 4):340-7. doi: 10.1046/j.1469-1809.2003.00029.x.

DOI:10.1046/j.1469-1809.2003.00029.x
PMID:12914568
Abstract

Allele frequencies for 17 STR loci were analyzed in a sample of unrelated males from the Cabo Verde Archipelago. The samples were gathered in such a way that the origin of the subjects was perfectly identified, and they could be included in one of the leeward or windward groups of islands. This study reveals that there are significant differences between both groups of islands, and between Cabo Verdeans and other populations from sub-Sahara Africa including the Guineans, the most probable source population for Cabo Verdeans. This study confirms mtDNA data and, together with HLA and Y chromosome data already published, shows that the Cabo Verde population is sub-structured and atypical, diverging substantially from mainland sub-Saharan populations. Overall these differences are most probably due to admixture between sub-Saharan slaves brought into the islands and other settlers of European origin. In the absence of a clear indication of a different ethnic composition of the first sub-Saharan settlers of Cabo Verde, the differentiation exhibited in both groups of islands can be most probably be attributed to genetic drift.

摘要

在佛得角群岛的一组无亲缘关系男性样本中,分析了17个短串联重复序列(STR)位点的等位基因频率。样本采集方式能完美确定受试者的来源,他们可被归入背风群岛组或迎风群岛组。本研究表明,两组岛屿之间、佛得角人与撒哈拉以南非洲的其他人群(包括几内亚人,佛得角人最可能的源人群)之间存在显著差异。本研究证实了线粒体DNA(mtDNA)数据,并与已发表的人类白细胞抗原(HLA)和Y染色体数据一起表明,佛得角人群存在亚结构且不典型,与撒哈拉以南非洲大陆人群有很大差异。总体而言,这些差异很可能是由于被带到这些岛屿的撒哈拉以南奴隶与其他欧洲裔定居者之间的混合。由于没有明确迹象表明佛得角最早的撒哈拉以南定居者有不同的种族构成,两组岛屿中表现出的差异很可能归因于基因漂变。

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