Klibanski Anne
Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, BUL457B, Boston, MA 02114, USA.
Growth Horm IGF Res. 2003 Aug;13 Suppl A:S109-15. doi: 10.1016/s1096-6374(03)00065-0.
The association of hypopituitarism and growth hormone (GH) deficiency with increased cardiovascular mortality has become increasingly well established. In GH-deficient adults, whether the onset of disease is in childhood or in adult life, a higher prevalence of atherosclerotic plaques and endothelial dysfunction has been described. Of note, high-resolution ultrasonography has shown that patients with hypopituitarism have a higher prevalence of premature atherosclerosis even in the absence of clinical symptoms. Specific anatomic abnormalities also have been described in adults with GH deficiency, including an increase in intimal-medial wall thickness. The contribution of specific hormonal factors and prior irradiation to the development of vascular disease remains controversial.
垂体功能减退症和生长激素（GH）缺乏与心血管死亡率增加之间的关联已越来越明确。在生长激素缺乏的成年人中，无论疾病是在儿童期还是成年期发病，动脉粥样硬化斑块和内皮功能障碍的患病率都较高。值得注意的是，高分辨率超声检查显示，即使没有临床症状，垂体功能减退症患者过早发生动脉粥样硬化的患病率也较高。在生长激素缺乏的成年人中也描述了特定的解剖学异常，包括内膜-中膜厚度增加。特定激素因素和既往放疗对血管疾病发展的影响仍存在争议。
