Péter Ferenc
Buda Children's Hospital, 1023, Budapest, Bolyai-u. 5-7, Hungary.
Growth Horm IGF Res. 2003 Aug;13 Suppl A:S136-42. doi: 10.1016/s1096-6374(03)00070-4.
The main aim of sex steroid replacement during induction of puberty is to obtain a balance between healthy psychological and somatic development and optimal final height and peak bone mass (PBM). At present, the age at which it is considered appropriate to begin inducing puberty is younger than it was in the past. This trend aims for optimisation of prepubertal and pubertal growth through earlier onset of growth hormone (GH) therapy and administration of higher doses during puberty as necessary. Adequate initiation of puberty should ensure not only optimal final height and psychological balance, but also normal body proportions, appropriate bone formation and preservation of fertility for children with GH and gonadotropin deficiencies.
青春期诱导期间进行性类固醇替代的主要目的是在健康的心理和身体发育与最佳最终身高及峰值骨量（PBM）之间取得平衡。目前，开始诱导青春期的适宜年龄比过去更小。这一趋势旨在通过更早开始生长激素（GH）治疗以及在青春期必要时给予更高剂量来优化青春期前和青春期的生长。对于患有GH和促性腺激素缺乏症的儿童，适当启动青春期不仅应确保最佳最终身高和心理平衡，还应保证正常的身体比例、适当的骨形成以及生育能力的保留。
