Muddeshwar M G, Nath N, Chari S N
Department of Biochemistry, Indira Gandhi Medical College, Nagpur.
Indian J Physiol Pharmacol. 1992 Oct;36(4):263-6.
Male and female albino rats of same age and body weight were pair fed with laboratory stock diet and ascorbic acid, dehydroascorbic acid and diketogulonic acid were determined in the liver and urine, while in blood only ascorbic acid was estimated. Male rats had concentration higher of ascorbic acid in liver and urine as compared with females, while there were no significant variations in the contents of dehydroascorbic acid and diketogulonic acid. Hepatic and renal 2, 3-diketoaldonate decarboxylase, and hepatic dehydroascorbatase were also found to be significantly higher in male rats. Similar sex variations were also observed in ascorbic acid catabolism in guinea pigs without any differences in urinary ascorbic acid contents.
选用年龄和体重相同的雄性和雌性白化病大鼠，用实验室储备饲料进行配对喂养，并测定肝脏和尿液中的抗坏血酸、脱氢抗坏血酸和二酮古洛糖酸，而血液中仅测定抗坏血酸。与雌性大鼠相比，雄性大鼠肝脏和尿液中的抗坏血酸浓度更高，而脱氢抗坏血酸和二酮古洛糖酸的含量没有显著差异。还发现雄性大鼠肝脏和肾脏中的2,3-二酮醛酸脱羧酶以及肝脏中的脱氢抗坏血酸酶显著更高。在豚鼠的抗坏血酸分解代谢中也观察到了类似的性别差异，而尿中抗坏血酸含量没有差异。
