Lancaster Jack R
Center for Free Radical Biology, Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Trends Pharmacol Sci. 2003 Aug;24(8):389-91. doi: 10.1016/S0165-6147(03)00199-8.
Sickle cell disease (SCD) is characterized by malformed erythrocytes and results in many vascular complications, including the lysis of a minor proportion of these cells, liberating free hemoglobin, which is a potent scavenger of nitric oxide (NO). SCD involves inflammatory activation, including the upregulation of vascular coagulation. Because NO possesses important anti-coagulant and anti-adhesion properties, the increased scavenging of NO in SCD undoubtedly is a major contributor to the pathology of this disease.
镰状细胞病（SCD）的特征是红细胞畸形，并导致许多血管并发症，包括一小部分这类细胞的裂解，释放出游离血红蛋白，而游离血红蛋白是一种强大的一氧化氮（NO）清除剂。SCD涉及炎症激活，包括血管凝血的上调。由于NO具有重要的抗凝和抗黏附特性，SCD中NO清除增加无疑是该疾病病理的主要促成因素。
