Ro Hyunju, Kim Kyoon E, Huh Tae L, Lee Sang-Kyu, Rhee Myungchull
Department of Biology, College of Natural Sciences Chungnam National University, Daejeon 305-764, South Korea.
Gene Expr Patterns. 2003 Aug;3(4):483-8. doi: 10.1016/s1567-133x(03)00061-9.
Siah is a mammalian homolog of Drosophila seven in absentia (SINA). Here we report the identification of a new member of the SINA/Siah gene family. This new gene, designated Siaz, was found in zebrafish, and its product is predicted to share extensive amino acid sequence homology with Drosophila SINA. Siaz is maternally inherited, with zygotic expression in all blastomeres starting at the mid-blastula transition. After the 20-somite stage, Siaz expression occurs in a stage-specific manner in particular regions, including the brain, eye, cranial cavity, otic vesicle, optic chiasm and gut.
Siah是果蝇无七（SINA）的哺乳动物同源物。在此，我们报告了SINA/Siah基因家族一个新成员的鉴定。这个新基因被命名为Siaz，在斑马鱼中被发现，其产物预计与果蝇SINA具有广泛的氨基酸序列同源性。Siaz是母系遗传的，在囊胚中期转变开始时，所有卵裂球中都有合子表达。在20体节期之后，Siaz在特定区域以阶段特异性方式表达，包括脑、眼、颅腔、耳泡、视交叉和肠道。
