de Roos N M, Schouten E G, Katan M B
Wageningen University, The Netherlands.
Eur J Med Res. 2003 Aug 20;8(8):355-7.
A high consumption of trans fatty acids increases the risk of cardiovascular disease (CVD). We investigated whether this increase in risk was due to the decrease in serum HDL-cholesterol by trans fatty acids, because low concentrations of serum HDL-cholesterol also increase risk of CVD. Flow-mediated vasodilation (FMD) was used as an endpoint in dietary interventions that were designed to change the concentration of serum HDL-cholesterol within 4 weeks in healthy volunteers. Replacement of 10% of energy from saturated by trans fatty acids decreased serum HDL-cholesterol by 21 % and impaired FMD. However, a replacement of monounsaturated fats by carbohydrates did not impair FMD, although it decreased serum HDL-cholesterol by 13%. Acute postprandial impairments of FMD by either trans fats or saturated fats were not found, suggesting that long-term effects are responsible for the detrimental effect of trans fats on health. However, the role of serum HDL-cholesterol appears to be less than we expected.
大量摄入反式脂肪酸会增加心血管疾病（CVD）的风险。我们研究了这种风险增加是否是由于反式脂肪酸导致血清高密度脂蛋白胆固醇（HDL-胆固醇）降低所致，因为血清HDL-胆固醇浓度低也会增加CVD风险。在旨在使健康志愿者血清HDL-胆固醇浓度在4周内发生变化的饮食干预中，采用血流介导的血管舒张（FMD）作为终点指标。用反式脂肪酸替代10%来自饱和脂肪的能量，可使血清HDL-胆固醇降低21%，并损害FMD。然而，用碳水化合物替代单不饱和脂肪虽然使血清HDL-胆固醇降低了13%，但并未损害FMD。未发现反式脂肪或饱和脂肪对FMD有急性餐后损害作用，这表明长期影响是反式脂肪对健康产生有害作用的原因。然而，血清HDL-胆固醇的作用似乎比我们预期的要小。
