单纯疱疹病毒1型和2型gD的N端差异，这些差异影响与人类进入受体Nectin-2以及在中国仓鼠卵巢细胞中表达的一种进入受体的功能相互作用。
Differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 and an entry receptor expressed in Chinese hamster ovary cells.
作者信息
Zago Anna, Spear Patricia G
机构信息
Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
出版信息
J Virol. 2003 Sep;77(17):9695-9. doi: 10.1128/jvi.77.17.9695-9699.2003.
Abstract
Amino acid differences at seven positions in the N termini of the glycoproteins D (gDs) specified by herpes simplex virus type 1 (HSV-1) and HSV-2 are largely responsible for the significantly higher cell fusion activity of HSV-2 gD with Chinese hamster ovary cells expressing human nectin-2 or only an endogenous hamster receptor.
摘要
单纯疱疹病毒1型（HSV - 1）和HSV - 2所指定的糖蛋白D（gD）N端七个位置的氨基酸差异，在很大程度上导致了HSV - 2 gD与表达人nectin - 2或仅表达内源性仓鼠受体的中国仓鼠卵巢细胞具有显著更高的细胞融合活性。
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Differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 and an entry receptor expressed in Chinese hamster ovary cells.单纯疱疹病毒1型和2型gD的N端差异，这些差异影响与人类进入受体Nectin-2以及在中国仓鼠卵巢细胞中表达的一种进入受体的功能相互作用。
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本文引用的文献
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2
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Structural features of nectin-2 (HveB) required for herpes simplex virus entry.单纯疱疹病毒进入所需的nectin-2（HveB）的结构特征。
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