Moore Eva, Wisniewski Amy, Dobs Adrian
Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
J Clin Endocrinol Metab. 2003 Aug;88(8):3467-73. doi: 10.1210/jc.2002-021967.
Cross-sex hormone treatment is an important component in medical treatment of transsexual people. Endocrinologists are often faced with designing treatment recommendations. Although guidelines from organizations, such as the Harry Benjamin International Gender Dysphoria Association, have been helpful, management remains complex and experience guided. We discuss the range of treatment used by transsexual people, the rationale behind these, and the expectation from such treatment. Recommendations from seven clinical research centers treating transsexual people are discussed. In addition, self-reported hormonal regimens from 25 male-to-female transsexual people and five female-to-male transsexual people are reported. Finally, the potential adverse effects of cross-sex hormone treatment of transsexual people are reviewed. In light of the complexity of managing treatment goals and adverse effects, the active involvement of a medical doctor experienced in cross-sex hormonal therapy is vital to ensure the safety of transsexual people.
跨性别激素治疗是变性者医学治疗的重要组成部分。内分泌学家常常面临制定治疗建议的任务。尽管诸如哈利·本杰明国际性别焦虑症协会等组织发布的指南有所帮助，但治疗管理仍然复杂且需依据经验。我们讨论了变性者使用的治疗方法范围、其背后的原理以及对这种治疗的期望。探讨了七个治疗变性者的临床研究中心的建议。此外，还报告了25名男变女变性者和5名女变男变性者自我报告的激素治疗方案。最后，回顾了变性者跨性别激素治疗的潜在不良反应。鉴于管理治疗目标和不良反应的复杂性，有跨性别激素治疗经验的医生积极参与对于确保变性者的安全至关重要。
