Canosa Luis Fabián, Lin Xinwei, Peter Richard E
Department of Biological Sciences, University of Alberta, Edmonton, Alta, Canada.
Neuroendocrinology. 2003 Aug;78(2):81-9. doi: 10.1159/000071963.
In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In addition, estradiol also increased the pituitary expression of sst5. On the other hand, testosterone had no effects on the expression of these receptor subtypes. Mature female goldfish were found to have higher sst1 and sst5 expression in the pituitary, as well as a higher expression of sst1 in the forebrain compared to sexually regressed animals. As estradiol treatment increases serum growth hormone levels in goldfish, these data suggest that sst1 and sst5 receptors are likely not directly involved in this aspect of growth hormone release.
在本论文中，研究了雌二醇和睾酮对金鱼前脑和垂体中1型和5型生长抑素受体（sst1和sst5）表达的影响。雌二醇以前脑和垂体中sst1表达呈剂量和时间依赖性的方式增加。此外，雌二醇还增加了垂体中sst5的表达。另一方面，睾酮对这些受体亚型的表达没有影响。发现成熟雌性金鱼与性退化动物相比，垂体中sst1和sst5的表达更高，前脑中sst1的表达也更高。由于雌二醇处理会增加金鱼血清生长激素水平，这些数据表明sst1和sst5受体可能不直接参与生长激素释放的这一方面。
