Sayyah M, Saroukhani G, Peirovi A, Kamalinejad M
Department of Physiology & Pharmacology, Institute Pasteur of Iran, Pasteur avenue, Tehran, Iran.
Phytother Res. 2003 Aug;17(7):733-6. doi: 10.1002/ptr.1197.
The leaf essential oil of Laurus nobilis Linn. (Lauraceae) has been evaluated for antinociceptive and anti-inflammatory activities in mice and rats. The essential oil exhibited: (1) a significant analgesic effect in tail-flick and formalin tests; (2) a dose-dependent anti-inflammatory effect in the formalin-induced edema and (3) a moderate sedative effect at the anti-inflammatory doses. The analgesic and anti-inflammatory effect of the essential oil was comparable to reference analgesics and non-steroid anti-inflammatory drugs: morphine and piroxicam. Present results make the essential oil worthy of further investigations.
已对月桂（樟科）叶精油在小鼠和大鼠身上的抗伤害感受和抗炎活性进行了评估。该精油表现出：（1）在甩尾和福尔马林试验中有显著的镇痛作用；（2）在福尔马林诱导的水肿中具有剂量依赖性抗炎作用；（3）在抗炎剂量下有中度镇静作用。该精油的镇痛和抗炎作用与参考镇痛药和非甾体抗炎药：吗啡和吡罗昔康相当。目前的结果使该精油值得进一步研究。
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