Merrow Martha, Dragovic Zdravko, Tan Ying, Meyer Gundela, Sveric Kruno, Mason Moyra, Ricken Jan, Roenneberg Till
Institut für Medizinische Psychologie, Munich, Germany.
Chronobiol Int. 2003 Jul;20(4):559-75. doi: 10.1081/cbi-120023678.
This review is intended as a summary of our work carried out as part of the German Research Association (DFG) Center Program on Circadian Rhythms. Over the last six years, our approach to understanding circadian systems combined theoretical and experimental tools, and Gonyaulax and Neurospora have proven ideal for these efforts. Both of these model organisms demonstrate that even simple circadian systems can have multiple light input pathways and more than one rhythm generator. They have both been used to elaborate basic circadian features in conjunction with formal models. The models introduce the "zeitnehmer," i.e., a clock-regulated input pathway, to the conceptual framework of circadian systems, and proposes networks of individual feedbacks as the basis for circadian rhythmicity.
本综述旨在总结我们作为德国研究协会（DFG）昼夜节律中心项目的一部分所开展的工作。在过去六年中，我们理解昼夜节律系统的方法结合了理论和实验工具，事实证明，腰鞭毛虫和脉孢菌是开展这些研究的理想对象。这两种模式生物均表明，即使是简单的昼夜节律系统也可以有多个光输入途径和不止一个节律发生器。它们都被用于结合形式模型阐述基本的昼夜节律特征。这些模型将“授时因子”（即一种受时钟调节的输入途径）引入昼夜节律系统的概念框架，并提出个体反馈网络作为昼夜节律性的基础。
