中性条件下的酮合成。二苯基次膦酸亚铜介导、钯催化的硫醇酯与有机锡烷的偶联反应。
Ketone synthesis under neutral conditions. Cu(I) diphenylphosphinate-mediated, palladium-catalyzed coupling of thiol esters and organostannanes.
作者信息
Wittenberg Rüdiger, Srogl Jiri, Egi Masahiro, Liebeskind Lanny S
机构信息
Emory University, Department of Chemistry, 1515 Pierce Drive, Atlanta, Georgia 30322.
出版信息
Org Lett. 2003 Aug 21;5(17):3033-5. doi: 10.1021/ol034962x.
PMID:12916974
Abstract
[reaction: see text] A versatile approach to ketone synthesis is described. The reaction relies on the palladium-catalyzed, copper diphenylphosphinate-mediated coupling of thiol esters with organostannanes under neutral reaction conditions. This reaction complements the previously described coupling of thiol esters with boronic acids that used dual thiophilic-borophilic activation methodology.
摘要
[反应：见正文] 描述了一种通用的酮合成方法。该反应依赖于在中性反应条件下，钯催化、二苯基次膦酸铜介导的硫醇酯与有机锡烷的偶联反应。此反应补充了先前所述的使用双亲硫-亲硼活化方法的硫醇酯与硼酸的偶联反应。
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