Nieuwenhuizen Jeroen, Watson Peter G, Emmanouilidis-van der Spek Katinka, Keunen Jan E E, Jager Martine J
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Ophthalmology. 2003 Aug;110(8):1653-66. doi: 10.1016/S0161-6420(03)00487-1.
To determine the value of anterior segment indocyanine green (ICG) angiography combined with anterior segment fluorescein angiography in scleral inflammation.
Comparative observational case series.
The study included 18 patients with various forms of scleral and episcleral disease and a single normal subject.
Anterior segment angiography using both ICG and fluorescein was performed to identify any vascular abnormalities and pathologic changes in the anterior segment.
The pathologic criteria for anterior segment fluorescein angiography described by Watson and Bovey (1995) were used to compare and contrast the results of the angiograms.
Fluorescein angiography and ICG angiography provide different and complementary information. Both dyes have different leakage patterns caused by their difference in optical and chemical properties. Areas of slow flow are more readily determined with fluorescein angiography. ICG angiography determines damage to and patency of individual vessels.
Fluorescein angiography and ICG angiography detect areas of damage not clinically visible and can be useful in the differential diagnosis, the selection of appropriate medication, and monitoring and regulation of treatment in scleritis. To obtain the most information both investigations should be performed sequentially.
确定眼前节吲哚菁绿（ICG）血管造影联合眼前节荧光素血管造影在巩膜炎症中的价值。
比较观察性病例系列。
该研究纳入了18例患有各种形式巩膜和巩膜表层疾病的患者以及1名正常受试者。
使用ICG和荧光素进行眼前节血管造影，以识别眼前节的任何血管异常和病理变化。
采用Watson和Bovey（1995年）描述的眼前节荧光素血管造影的病理标准来比较和对比血管造影的结果。
荧光素血管造影和ICG血管造影提供了不同且互补的信息。两种染料因其光学和化学性质的差异而具有不同的渗漏模式。荧光素血管造影更容易确定血流缓慢的区域。ICG血管造影可确定单个血管的损伤和通畅情况。
荧光素血管造影和ICG血管造影可检测出临床上不可见的损伤区域，有助于巩膜炎的鉴别诊断、选择合适的药物以及监测和调整治疗。为了获得最多的信息，两项检查应依次进行。
