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[通过静脉输注乳蛋白对失血性休克后期犬的止血系统功能紊乱及血液流变学特性的纠正]

[The correction of functional disorders of the hemostatic system and of the rheological properties of the blood in dogs in the late period of hemorrhagic shock by the intravenous transfusion of lactoprotein].

作者信息

Oborin A N, Uspenskiĭ B A, Kondratskiĭ B A, Mindiuk M V

出版信息

Klin Khir (1962). 1992(9-10):25-8.

PMID:1291772
Abstract

In 9 dogs with severe hemorrhagic shock, the effect of hemocorrector "Lactoprotein" on the indices of coagulative hemostasis and rheologic blood properties was studied. It was established that in intravenous transfusion of lactoprotein at a dose of 10 ml/kg permitting to lead the animals out from the state of shock, the syndromes of disseminated intravascular coagulation and high viscosity of the blood were cupped off. However, by the end of 48 hours of observation, fibrinogen level in the blood of the animals increased sharply, while antithrombin-III concentration and hematocrit decreased. Together with recommendation to use lactoprotein in the complex of shock therapy at all the stages of medical evacuation, the conclusion about necessity to perform at the early postshock period the differential component hemo- and anticoagulative therapy has been made.

摘要

在9只患有严重失血性休克的犬中,研究了血液校正剂“乳蛋白”对凝血止血指标和血液流变学特性的影响。结果表明,以10毫升/千克的剂量静脉输注乳蛋白可使动物脱离休克状态,从而消除弥散性血管内凝血综合征和血液高粘度。然而,在观察48小时结束时,动物血液中的纤维蛋白原水平急剧上升,而抗凝血酶III浓度和血细胞比容则下降。在建议将乳蛋白用于医疗后送各阶段休克治疗综合方案的同时,得出了在休克后早期进行差异化成分血液和抗凝治疗的必要性的结论。

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