Garcia-Velasco Juan A, Arici Aydin
Instituto Valenciano de Infertilidad-Madrid, Madrid, Spain.
Semin Reprod Med. 2003 May;21(2):165-72. doi: 10.1055/s-2003-41323.
Apoptosis is a physiologic process that deletes unwanted cells without inducing an inflammatory reaction. Survival of endometriotic implants is associated with decreased apoptosis and an inflammatory environment. The most widely accepted theory-transplantation theory-related to the pathogenesis of endometriosis is supported by the description of abnormal survival of regurgitated endometrial cells. Eutopic endometrial cells from women with endometriosis also seem to resist apoptosis further when compared with cells from disease-free women. Several apoptotic pathways have been studied. Recent literature concerning apoptosis-related genes such as bcl-2/bax and fas/fas ligand is summarized in this article. Special emphasis is placed on sex steroid modulation and cell adhesion regulation, both relevant in early events of endometriosis.
细胞凋亡是一种生理过程，可清除不需要的细胞而不引发炎症反应。子宫内膜异位症植入物的存活与细胞凋亡减少及炎症环境有关。与子宫内膜异位症发病机制相关的最广泛接受的理论——移植理论，得到了反流子宫内膜细胞异常存活描述的支持。与无病女性的细胞相比，子宫内膜异位症女性的在位子宫内膜细胞似乎也更能抵抗细胞凋亡。已经对几种细胞凋亡途径进行了研究。本文总结了近期有关凋亡相关基因如bcl-2/bax和fas/fas配体的文献。特别强调了性激素调节和细胞黏附调节，这两者在子宫内膜异位症的早期事件中都具有相关性。
